University Chicago is among the centers participating in
a landmark clinical trial that has found that more
intensive management of high blood pressure (HBP)
reduces heart disease rates and saves lives.
trial included adults 50 years and older with HBP. It
found that adjusting BP medications (*)
to achieve a target top number of 120 mmHg reduced rates
of cardiovascular events by almost a third, and the risk
of death by almost a quarter, compared with targeting a
top number of 140 mmHg.
University Medical Center enrolled 89 patients in the
National Institutes of Health study, called the Systolic
Blood Pressure Intervention Trial (SPRINT).
the first clinical trial to confirm that a more
intensive BP regimen improves cardiovascular outcomes,"
said Holly Kramer, MD, principal investigator at the
Gibbons, MD, director of the National Heart, Lung, and
Blood Institute, the primary sponsor of SPRINT, said:
"The study provides potentially lifesaving information
that will be useful to health care providers as they
consider the best treatment options for some of their
patients, particularly those over age 50.
hypertension, is a leading risk factor for heart
disease, stroke, kidney failure and other health
problems. An estimated 1 in 3 people in the United
States have high blood pressure.
SPRINT study evaluates the benefits of maintaining a new
target for Systolic BP, the top number in a BP reading,
among a group of patients 50 years and older at
increased risk for heart disease or who have kidney
disease. A Systolic BP of 120 mmHg, maintained by this
more intensive BP intervention, could ultimately help
save lives among adults age 50 and older who have a
combination of HBP and at least one additional risk
factor for heart disease, the investigators say.
SPRINT was designed, the clinical guidelines recommended
a Systolic BP of less than 140 mmHg for healthy adults
and 130 mmHg for adults with kidney disease or diabetes.
Investigators designed SPRINT to determine the potential
benefits of achieving Systolic BP of less than 120 mmHg.
Lifestyle changes will also help lower Systolic BP
Mike Kohut, President, DDMS
Copyright: 2015 by DDMS & iMobLife